Hypotensive diet may prevent teen obesity

A study, published in the Archives of Pediatric and Adolescent Medicine, found that girls who followed basic principles of the Dietary Approach to Stop Hypertension (DASH) diet through their teens had a smaller tendency to gain an excess amount of weight by the time they reached early adulthood than teens who didn't stick to this diet.

The DASH diet centers around high consumption of low-fat dairy products, fish, chicken, and lean cuts of beef, as well as nuts, fruits, whole grains, vegetables, and legumes. This is the diet that’s recommended by the US government in its dietary guidelines.

The research, which surveyed more than 2,300 girls on their eating habits during 10 annual visits beginning at age 9, found that those whose eating patterns were closest to the DASH diet had an average body mass index of 24 (considered a healthy weight) by age 18, compared with a BMI of 26 (considered overweight) for those who didn't follow DASH.

The diet plan boils down to eating mostly whole foods while minimizing intake of processed cakes, cookies, and chips. But it's not necessarily about reducing calories. Those in the study who followed a DASH-style diet actually ate, on average, more than 250 extra calories a day compared with those who consumed a lot more high-fat meats, cheeses, and junk food.

On the other hand, the girls who were better eaters were more physically active and watched less TV -- two factors that also help protect against obesity.

Source: http://www.boston.com/lifestyle/health/blog/dailydose/2011/06/study_suggest_d.html

Naringenin, a compound from grapefruit, helping to reduce insulin resistance

A complex of naringenin and cyclodextrin may help to substantially reduce the absorption of fat and sugar in the body, according to study published in PLoS One.

The research team, from Harvard and the Hebrew University of Jerusalem, found their complex increases the absorption of naringenin by 11 times. They reported that a single dose given to rats before a meal reduced the generation of very low density lipoprotein (VLDL) by 42 per cent, whilst insulin sensitivity was boosted by 64 per cent. The authors claim that their research is the first demonstration that a dietary supplement can change the way our body can react beneficially to a meal.

In recent years, polyphenols, and flavonoids in particular, have emerged as a class of natural products shown to have anti-oxidant, anti-atherogenic, and normolipidemic effects. One of the most abundant flavonoids is the citrus flavonoid-glycoside naringin, which is broken down into naringenin.

Previous research has previously shown that naringenin, responsible for the bitter taste in grapefruits, could potentially be used in the treatment of diabetes, arteriosclerosis and hyper-metabolism. However,  the absorption of naringenin in its natural form is usually very low, reducing its bioavailability. The solubility and transport through the intestinal epithelium of naringenin can be enhanced by forming a complex with a chyclodextrin.

When the complex was administered to rats just prior to a meal it caused a decrease in VLDL levels by 42% and increased the rate of glucose clearance by 64% compared to naringenin alone.

Source: PLoS ONE
Published online ahead of print, doi:10.1371/journal.pone.0018033
“Enhancement of Naringenin Bioavailability by Complexation with Hydroxypropoyl-β-Cyclodextrin”
Authors: M. Shulman, M. Cohen, A. Soto-Gutierrez, H. Yagi, H. Wang, et al