Are diet and exercise enough to lose weight and keep it low?

A new study, published in The New England Journal of Medicine, shows that regaining weight after a period of diet and exercise may be inevitable due to hormones.

Australian researchers found that after losing weight, hormone levels - particularly those that influence hunger - shifted in the body, leading to increase appetites and weight regain.

The study involved 50 adults with a body mass index (BMI) between 27 and 40, who were on a diet and exercise for 10 weeks. After an initial loss scientists found that the levels of appetite-regulating hormones changed, resulting in a regain of 1/3 of the lost weight over the course of a year.

The results of the Australian study corroborate findings in another paper released earlier this year, in which researchers from Spain confirmed that people with high levels of the hormone leptin and low levels of ghrelin are more likely to gain the weight they lost.

Instead of playing the diet and exercise message on repeat - an ineffective longterm weight loss strategy for some - the Spanish authors suggested that endocrinologists and nutritionists consider the possibility of hormonal imbalances when developing weight loss strategies.

Source: http://www.nydailynews.com/life-style/health/diet-exercise-fight-obesity-study-article-1.971052#ixzz1cjDgPJ3S

New drug to prevent pregnant obese women to give birth to obese babies

A UK trial will soon be under way whereby a commonly used diabetes pill will be administered to obese pregnant women in an attempt to prevent overweight mothers from delivering obese babies.

Obese women who become pregnant are generally at risk of complications such as pre-eclampsia (potentially fatal), fetal death, possible birth defects and a greater number of caesarean deliveries. Children born to obese mothers are twice as likely to be obese and to develop type 2 diabetes later in life. Obesity during pregnancy is also associated with greater use of health care services and a longer hospital stay.

Given the disturbing trend of increasing obesity among women in many developed countries, the answer is, apparently, to counter this by medicating babies while still in the womb. The trial will involve 100 obese but non-diabetic volunteers at hospitals in Liverpool and Coventry, England and Edinburgh, Scotland. Half will take the drug Metformin after the first trimester of their pregnancies and the other half will take a placebo.

Many weight loss groups and others feel that this news is most disturbing and gives the message that there is a solution to conditions such as obesity, which involve simply taking a pill as a "cure". The emphasis, they feel, should be on encouraging mothers-to-be to lose excess weight before even considering bringing a child into the world.

Studies have consistently shown that lifestyle modification that includes a healthy diet, regular exercise and weight management can prevent the many and various conditions associated with obesity, such as diabetes, gestational diabetes mellitus, and so on.

The ethics of medicating babies while in the womb, or the possible long-term effects of administering drugs of this nature, are also reasons for concern.

Source: http://www.telegraph.co.uk/health/h...

Sleep deprivation may cause weight gain

A new European study published in the American Journal of Clinical Nutrition augments existing evidence that sleep deprivation can lead to weight gain, not only by increasing appetite, but also by slowing metabolism.

The research conducted in Uppsala University in Sweden found that as little as a single night's sleep deprivation can significantly lower energy expenditure in healthy men. This indicates that sleep plays a prominent role in determining daytime energy production. Previous research has revealed an association between sleep loss and weight gain and also has found that sleep disorders affect blood levels of stress and hunger hormones. In a quest to determine the exact means by which a lack of sleep affects weight, the team of investigators induced differing degrees of sleep conditions in 14 male college students. They divided the men into three groups, consisting of no sleep, normal sleep and limited sleep. The men were then assessed in regard to alterations in factors such as metabolic rate and amount of food consumed.

The energy outlay for activities such as breathing and digestion was lessened by 5 to 20 percent. Higher levels of appetite-regulating hormones and stress hormones were also noted. Even though the appetite hormones were affected, the men did not eat more during the day.

Although research data is inadequate to prove the link between sleep loss and weight gain, evidence is quite sufficient to suggest it. Data collected over the past 50 years reveals an inverse relationship between obesity rates and average sleep time, with the highest obesity percentages found in adults getting the least amount of sleep.

Source: http://www.reuters.com/article/2011/05/16/uk-health-sleep-idUSLNE74F02320110516

Researchers Identify Pathways Leading to Activation of 'Good' Fat

Brown fat, burns energy rather than storing it, which the more common white fat does. The study, published in the October issue of Endocrinology, sought to learn more about how to get brown fat cells to grow. It identified two molecular pathways that lead to a protein called necdin that blocks brown fat growth.

With this information, researchers can look for ways to modify the steps along the pathways, either to stimulate another protein, called CREB, which shuts down necdin, or block a different protein called FoxO1, located along the second pathway, which stimulates necdin. The study showed for the first time that the two proteins can bind directly to the necdin gene.

One pathway to necdin starts with insulin cells and runs through proteins called Ras and ERK1/2 before getting to CREB. The second also starts with insulin and runs through proteins called P13-K and Akt before getting to FoxO1.

This is the latest in a series of studies on brown fat led by Drs. Cypess and Tseng. In July, Dr. Cypess and his team showed that brown fat can be seen on imaging studies in nearly half of all children and is most active in those who are thin. The amount of the fat also increases in children up until puberty, when it begins to decline, according to that study, published in the Journal of Pediatrics.

In 2009, Dr. Cypess and his team demonstrated in the New England Journal of Medicine for the first time that brown fat is metabolically active in adult humans. Previously, it had been thought that brown fat was present only in babies and children. The 2009 study showed it was found to be active under normal living conditions in 5.4 percent of all adults, with higher rates in women.

Source: http://www.sciencedaily.com/releases/2011/09/110921075423.htm