Consciousness of self weight is important for weight loss

Do we have a real perpception of our weight? Do we know if we are really overweight or not? This is what researchers at the University of Illinois investigated when they surveyed over 3,500 college applicants, as part of the Up Amigos project, a collaboration with the Mexican Universidad Autónoma de San Luis Potosi. More than a third couldn't report their weight accurately, and overweight and obese men were more likely to underestimate their weight than women. 

In contrast to what one would thought, almost half of the male volunteers underestimated their weight. Females were more realistic, as 21.2% believed that they were overweight when 27.8% of women were actually overweight or obese. This is even more worrying in the adolescence. According to figures released by the Centers for Disease Control and the International Journal of Pediatric Obesity, American teens are even less likely to report their weights correctly.

Very few participants in the Mexican study overestimated their weight, but those who did were most often female, younger, had parents with less education, and watched more television. Ideal body image changes with exposure to Western media, the researchers noted. The curvier female figure once appreciated in Latino culture is being replaced by the ultra-thin ideal promoted by Western advertisers.

Genes that can increase the risk of childhood obesity

The Center for Applied Genomics at The Children's Hospital of Philadelphia declare tha they have identified and characterized a genetic predisposition to common childhood obesity. The meta-analysis, by an international collaborative group, the Early Growth Genetics (EGG) Consortium, was published in Nature Genetics, and included 14 previous studies encompassing 5,530 cases of childhood obesity and 8,300 control subjects, all of European ancestry.

Previous studies had identified gene variants contributing to obesity in adults and in children with extreme obesity, but relatively little is known about genes implicated in regular childhood obesity. The study team identified two novel loci, one near the OLFM4 gene on chromosome 13, the other within the HOXB5 gene on chromosome 17. Both loci presented associactions with adult and extreme childhood obesity. However, none of the genes were previously implicated in obesity and although it is known they have functions in the intestine, their precise functional role in obesity is currently unknown.

Source: http://www.ncbi.nlm.nih.gov/pubmed/22484627

Obesity in mice can be ameliorated by transplantation of hypothalamic neurons

The db/db mouse is widely employed as model of morbid obesity and its main feature is that it lacks of the receptor of a hormone called leptin. This hormone plays a major role in the hypothalamus, were things like sleep, thirst, body temperature, and hunger are regulated.

In a recent study published in Science, Czupryn et al., showed that increasing leptin-receptor containing neurons in the hypothalamus could work to help db/db mice to reduce weight. They took newborn db/db mice and controls, and gave them an implant of neurons containing the leptin receptor. After the mice grew up, the authors found that the neurons were able to express the leptin receptor in the hypothalamus. The result was a lower body weight in mice treated with the leptin expressing neurons compared to non-treated db/db mice, but not as low as control mice.

Still, though it’s not the whole answer, it’s an interesting start to understanding not only the role of the hypothalamus in obesity and type 2 diabetes, but also how we might be able to change receptors in the brain to restore leptin sensitivity, and decrease sever obesity and the type 2 diabetes that often goes with it.

Source: Scientific American and
Czupryn, A., Zhou, Y., Chen, X., McNay, D., Anderson, M., Flier, J., & Macklis, J. (2011). Transplanted Hypothalamic Neurons Restore Leptin Signaling and Ameliorate Obesity in db/db Mice Science, 334 (6059), 1133-1137

Doctors need to be honest with their patients and say ‘Your kid’s overweight’

According to a study published online in Archives of Pediatrics & Adolescent Medicine, doctor should tell parents when their children are overweight as this would improve their motivation to follow healthy eating and activity.

Perrin and co-authors Asheley Cockrell Skinner, and Michael J. Steiner, performed a secondary statistical analysis of data collected from 4,985 children ages 2 to 15 years old who had a body mass index (BMI) at or above the 85th percentile based on measured height and weight. The data were collected as part of the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2008.

During that time, only 22 percent of parents reported that a doctor or other health professional told them their child was overweight. This percentage increased from 19.4 percent in 1999 to 23.4 percent in 2004, and then to 29.1 percent in 2007-2008. Even among parents of very obese children, only 58 percent recall a doctor telling them.

However, as shown in the journal Pediatrics parents are reluctant to be told that their children have an unhealthy weight.

Source: http://www.sciencedaily.com/releases/2011/12/111205165122.htm

Focus on an "obesogenic" environment rather than kids behavior to battle obesity

According to researchers reviewing numerous anti-childhood obesity programs, the focus to prevent it should be on strategies that seek to change children’s environments rather than their behavior.

The researchers said that environmental approaches improving physical activity and dietary habits are the key to prevention measures.

To find which forms of intervention could have a maximum effect to help prevent obesity in children, an international team of researchers updated a previous Cochrane Review by searching for new evidence from existing studies to see which forms of intervention work best.

Researchers targeted children ages 6-12 with school-based programs that encourage healthy eating, physical activity, and positive attitudes to body image.

The researchers highlighted the key strategies that could be considered for prevention measures including healthy eating, physical activity and body image in school curricula.

The key findings are:

• Increasing physical activity and the development of fundamental movement skills during the school week.
• Improving the nutritional quality of food supplied in schools.
• Creating environments and cultural practices within schools that support children eating healthier foods and being active throughout each day.
• Professional development and capacity building activities which help to support teachers and other staff as they implement health promotion strategies and activities.
• Giving more attention to parent support and home activities that encourage children to be more active, eat more nutritious foods and spend less time in screen-based activities.

Source: http://www.medicaldaily.com/news/20111207/8141/how-to-prevent-childhood-obesity-prevention-measures-for-child-obesitywatch-your-child%C3%A2%E2%82%AC%E2%84%A2s-dietch.htm

Are diet and exercise enough to lose weight and keep it low?

A new study, published in The New England Journal of Medicine, shows that regaining weight after a period of diet and exercise may be inevitable due to hormones.

Australian researchers found that after losing weight, hormone levels - particularly those that influence hunger - shifted in the body, leading to increase appetites and weight regain.

The study involved 50 adults with a body mass index (BMI) between 27 and 40, who were on a diet and exercise for 10 weeks. After an initial loss scientists found that the levels of appetite-regulating hormones changed, resulting in a regain of 1/3 of the lost weight over the course of a year.

The results of the Australian study corroborate findings in another paper released earlier this year, in which researchers from Spain confirmed that people with high levels of the hormone leptin and low levels of ghrelin are more likely to gain the weight they lost.

Instead of playing the diet and exercise message on repeat - an ineffective longterm weight loss strategy for some - the Spanish authors suggested that endocrinologists and nutritionists consider the possibility of hormonal imbalances when developing weight loss strategies.

Source: http://www.nydailynews.com/life-style/health/diet-exercise-fight-obesity-study-article-1.971052#ixzz1cjDgPJ3S

New drug to prevent pregnant obese women to give birth to obese babies

A UK trial will soon be under way whereby a commonly used diabetes pill will be administered to obese pregnant women in an attempt to prevent overweight mothers from delivering obese babies.

Obese women who become pregnant are generally at risk of complications such as pre-eclampsia (potentially fatal), fetal death, possible birth defects and a greater number of caesarean deliveries. Children born to obese mothers are twice as likely to be obese and to develop type 2 diabetes later in life. Obesity during pregnancy is also associated with greater use of health care services and a longer hospital stay.

Given the disturbing trend of increasing obesity among women in many developed countries, the answer is, apparently, to counter this by medicating babies while still in the womb. The trial will involve 100 obese but non-diabetic volunteers at hospitals in Liverpool and Coventry, England and Edinburgh, Scotland. Half will take the drug Metformin after the first trimester of their pregnancies and the other half will take a placebo.

Many weight loss groups and others feel that this news is most disturbing and gives the message that there is a solution to conditions such as obesity, which involve simply taking a pill as a "cure". The emphasis, they feel, should be on encouraging mothers-to-be to lose excess weight before even considering bringing a child into the world.

Studies have consistently shown that lifestyle modification that includes a healthy diet, regular exercise and weight management can prevent the many and various conditions associated with obesity, such as diabetes, gestational diabetes mellitus, and so on.

The ethics of medicating babies while in the womb, or the possible long-term effects of administering drugs of this nature, are also reasons for concern.

Source: http://www.telegraph.co.uk/health/h...

Caution bariatric surgery for adolescents

Weight-loss surgery for morbidly obese adolescents has become more popular even though many questions about safety and effectiveness remain, according to a commentary published in the New England Journal of Medicine.

Bariatric, surgery produces many benefits for most adult patients: they lose weight and can even have a complete reversal of diabetes. But less is known about the effects of the surgery on a young person who is just finished growing.

Several large and important studies are now underway to examine the risks and benefits of bariatric surgery on teens. Already, at least 1,000 teens a year are undergoing bariatric surgery in the USA despite the lack of long-term data on how the surgery affects them long-term. Until the data comes in from ongoing studies, doctors should tread cautiously in qualifying teens for surgery.

Source: http://www.latimes.com/health/boostershots/la-heb-bariatric-surgery-teens-20111012,0,4705997.story

Is there a link between air pollution and obesity?

Medical research has long supported the fact that exposure to ultrafine particulate matter increases the risk of various respiratory, cardiovascular, and pulmonary illnesses. Incidences of asthma, heart attacks, and chronic bronchitis are all higher in areas where the concentration of ultrafine particulate matter is higher. The correlation between particulate matter and these health issues is particularly pronounced in children, as well as low-income communities, which are often located closer to the sources of particulate matter (highways, factories, power plants) than their higher income neighbors.

Over the past decade, new studies have emerged that link air pollution to two of this country’s most pressing (and expensive) health epidemics: obesity and type II diabetes. Both are not only on the rise in terms of diagnoses, but also in terms of the costs associated with treatment. Even after controlling for factors such as genetics, income levels, weight, diet and exercise, Harvard researchers found a “consistent and significant” relationship between Type II diabetes prevalence and exposure to ultrafine particulate matter in a recent study published in Diabetes Care.

Results of an animal study published by Ohio State University researcher Qinghua Sun in late 2010 revealed that early exposure to ultrafine particulates led to the accumulation of abdominal fat and insulin resistance in mice even if they ate a normal diet. Exposure levels for animals in the study were similar to those found in U.S. cities.  The study compared mice fed a high-fat diet with those fed a normal, healthy diet, and exposed some members of both groups daily to ultrafine particulate matter, controlling for all other factors. In the end, all of the mice exposed to air pollution, including those fed a normal diet, had increased abdominal and subcutaneous (under the skin) fat.

These findings suggest that fine particulate pollution exposure alone, in the presence of a normal diet, may lead to an increase in fat cell size and number, and also have a proinflammatory effect.

Source: http://www.forbes.com/sites/amywestervelt/2011/10/10/two-new-reasons-to-worry-about-air-pollution-obesity-and-diabetes/

Fat cell formation may be inhibited by blueberry polyphenols

The latest research has shown that blueberry polyphenols may inhibit fat cell formation and increase lipolysis at the molecular level, suggesting the potential of polyphenols in reducing obesity risk through the reduction of adipose tissue production in the body. Plant polyphenols have shown to inhibit adipogenesis and to increase lipolysis. This action of polyphenols shows the positive effect plant based food constituents have on reducing body fat and inhibiting obesity.

The study utilized pre-adipocyte tissue to identify the effects of blueberry polyphenols on differentiation of unspecialized cells into adipocytes, or fat cells. Compared to the control tissue that received no polyphenols, the tissue exposed polyphenols showed significant reduction in lipid content (27% - 73%).

The polyphenols in blueberries and antioxidants in other fruits are showing important promise in the treatment of obesity. Research has shown an association with obesity and a decrease in the activity of antioxidants in the body. Another preliminary study shows early indications that oxidative stress can potentially lead to an increased development of fatty tissue.

Source: http://www.lef.org/newsletter/2011/0412_Blueberries-Inhibit-Fat-Cell-Formation.htm?source=eNewsLetter2011Wk15-1&key=Article&l=0